TOTAL HEALTH SOLUTIONS, INC.
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  • Home
  • About Us
  • Mission Statement
  • Nutraceuticals
  • Pure Encapsulations
  • Xymogen
  • Health Advisories
  • Relapse Prevention - RDS
  • Research & Clinical Studies
  • Video Consultation Payments
Most Recent Research

Genetic Addiction Risk Score (GARS): molecular neurogenetic evidence for predisposition to Reward Deficiency Syndrome (RDS). - PubMed - NCBI

Neurobiology of KB220Z-Glutaminergic-Dopaminergic Optimization Complex [GDOC] as a Liquid Nano: Clinical Activation of Brain in a Highly Functional C... - PubMed - NCBI
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Hypothesizing That Neuropharmacological and Neuroimaging Studies of Glutaminergic-Dopaminergic Optimization Complex (KB220Z) Are Associated With "Dopamine Homeostasis" in Reward Deficiency Syndrome (RDS)

The Benefits of Customized DNA Directed Nutrition To Balance The Brain Reward Circuitry And Reduce Addictive Behaviors - PubMed - NCBI

Neurophysiological Measures and Alcohol Use Disorder (AUD): Hypothesizing Links between Clinical Severity Index and Molecular Neurobiological Pattern - PubMed - NCBI

Pro-Dopamine Regulator - (KB220) to Balance Brain Reward Circuitry in Reward Deficiency Syndrome (RDS). - PubMed - NCBI

Genetic addiction risk score (GARS) ™, a predictor of vulnerability to opioid dependence. - PubMed - NCBI

Global Opioid Epidemic: Doomed To Fail Without Genetically Based Precision Addiction Medicine (Pam™): Lessons Learned From America. - PubMed - NCBI
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Coupling Genetic Addiction Risk Score (GARS) and Pro Dopamine Regulation (KB220) to Combat Substance Use Disorder (SUD). - PubMed - NCBI
Earlier KB220Z Research

Reward Deficiency Syndrome Studies of KB220 Variants and Molecular Neurobiology​

Enhanced functional connectivity and volume between cognitive and reward centers of naïve rodent brain produced by pro-dopaminergic agent KB220Z.

rsfMRI effects of KB220Z™ on neural pathways in reward circuitry of abstinent genotyped heroin addicts. - PubMed - NCBI

​Neurogenetics and gene therapy for reward deficiency syndrome: are we going to the Promised Land? - PubMed - NCBI

Can Genetic Testing Provide Information to Develop Customized Nutrigenomic Solutions for Reward Deficiency Syndrome? - PubMed - NCBI

Dopamine D2 gene expression interacts with environmental enrichment to impact lifespan and behavior. - PubMed - NCBI

The Psychoactive Designer Drug and Bath Salt Constituent MDPV Causes Widespread Disruption of Brain Functional Connectivity. - PubMed - NCBI

Common Neurogenetic Diagnosis and Meso-Limbic Manipulation of Hypodopaminergic Function in Reward Deficiency Syndrome (RDS): Changing the Recovery La... - PubMed - NCBI

Neuronutrient Amino-Acid Therapy Protects Against Reward Deficiency Syndrome: Dopaminergic Key to Homeostasis and Neuroplasticity. - PubMed - NCBI

Low-Resolution Electromagnetic Tomography (LORETA) of changed Brain Function Provoked by Pro-Dopamine Regulator (KB220z) in one Adult ADHD case. - PubMed - NCBI

Dopamine homeostasis: brain functional connectivity in reward deficiency syndrome. - PubMed - NCBI

KB220Z™ a Pro-Dopamine Regulator Associated with the Protracted, Alleviation of Terrifying Lucid Dreams. Can We Infer Neuroplasticity-induced Changes... - PubMed - NCBI

Lyme and Dopaminergic Function: Hypothesizing Reduced Reward Deficiency Symptomatology by Regulating Dopamine Transmission. - PubMed - NCBI

Overcoming qEEG abnormalities and reward gene deficits during protracted abstinence in male psychostimulant and polydrug abusers utilizing putative d... - PubMed - NCBI

A Shared Molecular and Genetic Basis for Food and Drug Addiction: Overcoming Hypodopaminergic Trait/State by Incorporating Dopamine Agonistic Therapy... - PubMed - NCBI

Clinically Combating Reward Deficiency Syndrome (RDS) with Dopamine Agonist Therapy as a Paradigm Shift: Dopamine for Dinner? - PubMed - NCBI

Pro-Dopamine Regulator - (KB220Z) to Balance Brain Reward Circuitry in Reward Deficiency Syndrome (RDS). - PubMed - NCBI

The Food and Drug Addiction Epidemic: Targeting Dopamine Homeostasis. - PubMed - NCBI

Click here for Clinical Studies from 1973-2016

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​TOTAL HEALTH SOLUTIONS, INC. TM
​T. Boland, ARNP, LMFT, Ph.D. ABD. FAARM
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